Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration
نویسندگان
چکیده
منابع مشابه
Mechanisms underlying hypoxia-induced neuronal apoptosis.
In vivo models of cerebral hypoxia-ischemia have shown that neuronal death may occur via necrosis or apoptosis. Necrosis is, in general, a rapidly occurring form of cell death that has been attributed, in part, to alterations in ionic homeostasis. In contrast, apoptosis is a delayed form of cell death that occurs as the result of activation of a genetic program. In the past decade, we have lear...
متن کاملNeuronal processes underlying rhythmic brain activity.
The neuroelectric activity of the brain provides a variety of instances of rhythmic events. The periodicity of such events ranges from milliseconds in the case of the firing of individual neurons t o circadian in the case of certain aspects of the "sleep" EEG. This paper will (be devoted t o a discussion of (i) methodological approaches to the detection and description of s6me of the shorter pe...
متن کاملModulation by Static Magnetism of Neuronal Activity
In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the ...
متن کاملMechanisms Underlying Modulation of Neuronal KCNQ2/KCNQ3 Potassium Channels by Extracellular Protons
Changes in extracellular pH occur during both physiological neuronal activity and pathological conditions such as epilepsy and stroke. Such pH changes are known to exert profound effects on neuronal activity and survival. Heteromeric KCNQ2/3 potassium channels constitute a potential target for modulation by H+ ions as they are expressed widely within the CNS and have been proposed to underlie t...
متن کاملBACE1 deficiency causes altered neuronal activity and neurodegeneration.
BACE1 is required for the release of beta-amyloid (Abeta) in vivo, and inhibition of BACE1 activity is targeted for reducing Abeta generation in Alzheimer's patients. To further our understanding of the safe use of BACE1 inhibitors in human patients, we aimed to study the physiological functions of BACE1 by characterizing BACE1-null mice. Here, we report the finding of spontaneous behavioral se...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2021
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2020.105155